Mutations with prognostic value in uveal melanoma. Analytical study of variants detected by targeted NGS.

Puntos clave

• This study aims to identify mutations in uveal melanoma that correlate with prognosis to improve patient outcomes.
• Analyzed mutations in genes BAP1, CHEK2, DICER1, and SF3B1 using targeted NGS.
• Evaluated the association of these mutations with patient prognosis.
• Classified histologic subgroups based on mutation presence.
• BAP1, CHEK2, and DICER1 mutations are linked to worse outcomes in uveal melanoma.
• SF3B1 mutations indicate a distinct histologic subgroup.
• Routine mutational profiling can enhance risk stratification and patient monitoring.