A high-stable atherogenic index of plasma trajectory over 12 years increased CVD risk by 31% (HR 1.31; 95% CI 1.03-1.67) versus low-stable in English adults.
Does a high-stable atherogenic index of plasma (AIP) trajectory increase the incidence of cardiovascular disease compared to a low-stable trajectory in an older English population?
A high and sustainable level of the atherogenic index of plasma over time is associated with an increased risk of incident cardiovascular disease in older adults.
Tasa de eventos absoluta: 0% vs 0%
Abstract Background/Introduction Atherogenic index of plasma (AIP) at baseline has been associated with increased morbidity and mortality from cardiovascular disease (CVD). However, the relationship between long-term AIP trajectories and CVD remains unclear. Purpose this study aimed to investigate the associations between AIP trajectories and the incidence of CVD in the English population. Method The study data analysis was based on the English Longitudinal Study of Aging (ELSA) from 2004 to 2017. AIP was calculated as log10 (triglycerides/high-density lipoprotein cholesterol). Group-based trajectory model (GBTM) was applied to identify the trajectory of the AIP index from Wave 2 to 8 over a 12-year follow-up. Cox proportional hazard models were then used to analyze the associations between different AIP index trajectory groups and the incidence of CVD. Results A total of 3,976 participants with completed AIP data in Wave 2 were enrolled in the ELSA cohort. The participants were divided into three groups low-stable group (n = 1,146), moderate-stable group (n = 2,110), high-stable group (n = 720) using a GBTM model. After adjusting for potential confounders, participants in the high-stable group indicated an increased risk of developing incident of CVD compared to those in the low-stable AIP group Hazard Ratio (HR): 1.31; 95% Confidence Interval (CI): 1.03-1.67, P = 0.026. However, no differences in the incidence of CVD (HR: 1.16, 95%CI: 0.95-1.40, P = 0.140) were observed in the moderate-stable group. Subgroup analysis indicated similar results for participants under 60 years old, male participants, smoking cessation, hypertension, and those without diabetes. Conclusions A high and sustainable level of the AIP index may contribute to the incidence of CVD. The trajectories of the AIP index can help identify older English individuals at increased risk of CVD who deserve primitive preventive and therapeutic approaches.AIP trajectories and incident of CVD The trajectory of AIP index over 12-year
Li et al. (Sat,) reported a other. A high-stable atherogenic index of plasma trajectory over 12 years increased CVD risk by 31% (HR 1.31; 95% CI 1.03-1.67) versus low-stable in English adults.