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February 8, 2026Molecular Diagnosis & Therapy0 citationsOpen Access

Interlesional Heterogeneity of EGFR Mutations: A Systematic Review and Meta-analysis

DSDiana Ivonne Rodríguez SánchezSÖSelin Asli ÖztürkOMOlga Maxouri

Key Points

  • To examine the heterogeneity of EGFR mutations across different contexts and samples in non-small cell lung cancer (NSCLC).
  • Conducted a systematic review of existing studies on EGFR mutations in NSCLC.
  • Performed a meta-analysis to derive pooled estimates from various sampling strategies and contexts.
  • Analyzed discrepancies based on factors such as biofluid and metastatic site.
  • EGFR mutation discordance observed frequently across studies.
  • Variability in mutation types noted depending on the sampling approach and treatment context.
  • Pooled estimates highlight the need for context-aware strategies in EGFR-targeted therapies.

Abstract

EGFR mutation discordance is common and clinically relevant, particularly in NSCLC, but varies substantially by sampling strategy, biofluid, treatment context, and metastatic site. Given the high between-study heterogeneity and the predominance of NSCLC and Asian cohorts, pooled estimates should be interpreted as descriptive summaries rather than universally generalisable benchmarks. These findings support integrated and context-aware sampling strategies for EGFR-targeted therapy and resistance monitoring.

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Cite This Study

Sánchez et al. (2026) studied this question.

synapsesocial.com/papers/698828410fc35cd7a884793ahttps://doi.org/10.1007/s40291-026-00829-6
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