A General Route to β,β-carbocyclic Sidechains in Peptides: An Aqueous Metallaphotoredox Approach Driven by Green Light

Key Points

• To explore a new method for introducing β,β-carbocyclic sidechains in peptides to enhance their properties.
• Utilized a metallaphotoredox approach under green light conditions.
• Synthesized β,β-carbocyclic amino acids as sidechains for incorporation into peptides.
• Analyzed effects on metabolic stability and cell permeability.
• Variations of peptides exhibited significantly improved metabolic stability.
• Increased cell permeability observed with β,β-carbocyclic sidechains compared to standard amino acids.