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February 8, 2026Organic & Biomolecular Chemistry0 citations

Amino acid derived chiral thioureas: design, synthesis and applications as NMR resolving agents for enantioselective recognition #

ABAshutosh V. BedekarRBRaymond J. ButcherADAstha M. Dwivedi

Key Points

  • This research aims to develop chiral thiourea derivatives from amino acids and explore their applications in enantioselective recognition.
  • Designed chiral thiourea compounds using amino acid scaffolds.
  • Synthesized the derivatives through specific chemical reactions.
  • Evaluated their effectiveness as NMR resolving agents.
  • Chiral thioureas showed strong hydrogen bonding capabilities.
  • Demonstrated reliable enantioselective recognition in various applications.
  • Proved effective in enhancing the resolution of NMR spectra.

Abstract

A new class of chiral thiourea derivatives derived from amino acids has been developed that harness the dual influence of strong hydrogen bonding and stereogenic amino acid scaffolds. Both unsymmetrical...

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Cite This Study

Bedekar et al. (2025) studied this question.

synapsesocial.com/papers/698828990fc35cd7a884838fhttps://doi.org/10.1039/d5ob02013a
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