A phenome-wide hunt for risk factors of Alzheimer’s disease: from metabolic clues to neuroimaging evidence

Puntos clave

• This research aims to identify potential risk factors for Alzheimer’s disease (AD) through metabolic and neuroimaging evidence.
• Conducted a phenome-wide association study.
• Analyzed metabolic markers and neuroimaging data.
• Assessed LDL-C metabolism in relation to AD.
• Disrupted LDL-C metabolism is suggested to causally contribute to AD.
• Identified correlations between metabolic clues and neuroimaging findings.