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February 8, 2026Age and Ageing

3690 Efficacy and safety of statin discontinuation in older people living with frailty: a UK population-wide study

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Authors

ASAnna SeeleyAWAndrew Z. WangJSJ Sheppard

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Overview

A population-wide study finds statin discontinuation affects hospitalisation and cardiovascular events in older frail individuals, indicating a need for tailored approaches.

Key Points

  • This study aims to assess the safety and efficacy of stopping statin medications in older individuals, specifically those with frailty.
  • Retrospective cohort study using CPRD data from 1998–2021.
  • Participants aged 65 and older with a statin medication possession ratio of ≥80%.
  • Matched exposed participants (discontinued statins) to unexposed participants (continued statins) at a 1:2 ratio.
  • Outcomes examined included all-cause hospitalisation and major adverse cardiovascular events (MACE).
  • Statistical analysis utilized Fine-Grey models and inverse probability of treatment weighting.
  • The cohort included 65,727 participants who stopped statins and 131,453 who continued.
  • One-year sub Hazard Ratios for hospitalisation and MACE were 1.22 and 1.3, respectively, with statin discontinuation.
  • In severely frail individuals, risks of hospitalisation and cardiovascular events were lower or non-significant over 1 and 5 years.
  • Discontinuation was associated with lower risks of statin-related side effects, like new diabetes, with a 5-year sHR of 0.79.

Cite This Study

Seeley et al. (2026) studied this question.

synapsesocial.com/papers/698828fd0fc35cd7a8848f0ehttps://doi.org/10.1093/ageing/afaf368.099
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France2019 · 165 citations
  2. 2Target trial emulation of statin discontinuation in multimorbid older adults with polypharmacy2025
  3. 3Discontinuation of statin therapy – an updated review2026
  4. 4The Statin Paradox: Drivers and Consequences of Therapy Discontinuation2026
  5. 5Rationale and design of ‘discontinuing statins in multimorbid older adults without cardiovascular disease (STREAM)’: study protocol of a randomised non-inferiority clinical trial2025