Investigate how the variation in FG-Nup sequence length influences the efficiency of nuclear pore complex translocation.
Analyzed the structure of nuclear pore complexes
Examined the positioning of FG-Nups based on length
Assessed translocation efficiency across nuclear pores
Identified that longer FG-Nups preferentially localize at the NPC periphery
Demonstrated enhanced selectivity of transport due to FG-Nup length variability
Revealed that shorter FG-Nups are less effective in translocating molecules
Abstract
The central channel of the nuclear pore complex (NPC) exhibits polydispersity in FG-nucleoporin (FG-Nup) sequence length, with longer FG-Nups on the periphery and shorter FG-Nups in the interior of the...