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February 8, 2026Open Access

Phylogenetic and structural analyses reveal Cdc2-like kinases (CLKs) as ancient regulators of thermosensitive splicing

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Authors

RORachel A. OgleJNJacob NethertonBRBenjamin R. Robinson

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Overview

Phylogenetic and structural analyses reveal ancient splicing regulators in diverse organisms, indicating evolutionary adaptation.

Key Points

  • This research aims to explore the evolutionary history and function of Cdc2-like kinases (CLKs) in different organisms.
  • Conducted phylogenetic analysis with 149 CLK homologs from 86 species.
  • Performed protein-interaction mapping to identify conserved CLK-interacting proteins across species.
  • Executed comparative structural modeling of CLK proteins.
  • Identified lineage-specific patterns of CLK gene loss and duplication.
  • Discovered 92 conserved CLK-interacting proteins, with functional differences in metazoans and yeast.
  • Found conservation of kinase domain structure, but variability in the CLK N terminus affects activity.

Cite This Study

Ogle et al. (2026) studied this question.

synapsesocial.com/papers/698829410fc35cd7a8849794https://doi.org/10.17169/refubium-51151
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