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February 9, 2026The Ocular Surface0 citationsOpen Access

Investigating conjunctival immune pathways in Sjögren and non-Sjögren disease associated dry eye

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KSKaitlin K. ScholandLSLaura SchaeferJSJianming Shao

Key Points

  • The aim is to explore immune pathways linked to dry eye disease (DED) in different diagnoses.
  • Analyzed transcriptomic data for immune-related differentially expressed genes (DEGs).
  • Compared findings between Sjögren and non-Sjögren dry eye conditions.
  • Examined pathways associated with DEGs on the ocular surface.
  • DED shows similar immune-related DEGs across different diagnoses.
  • Pathway analysis indicates common underlying immune mechanisms.
  • Findings support the idea of a unified immune response in dry eye disease.

Abstract

Our findings demonstrate that DED, regardless of the diagnosis, have similar immune-related DEGs and associated pathways on the ocular surface.

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Cite This Study

Scholand et al. (2026) studied this question.

synapsesocial.com/papers/698978dff0ec2af6756e7195https://doi.org/10.1016/j.jtos.2026.02.001
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