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February 9, 2026Nutrition & Metabolism0 citationsOpen Access

Sex-specific in the nonlinear associations of hemoglobin glycation index and all-cause mortality in the general US adult population: results from NHANES 1999–2018

CWChaolan WangKLKe LinHZHong Zhi Zhang

Key Points

  • To investigate sex-specific nonlinear associations between hemoglobin glycation index (HGI) and all-cause mortality.
  • Used NHANES 1999-2018 data
  • Analyzed mortality rates in relation to HGI
  • Compared associations between males and females
  • Observed a U-shaped pattern in males between HGI and mortality
  • Found an L-shaped association in females
  • Indicated distinct clinical implications based on sex

Abstract

The cohort study observed a U-shaped pattern between HGI and all-cause mortality in U.S. males, whereas an L-shaped association was found in females. These sex-specific patterns warrant further investigation to explore clinical implications.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69897983f0ec2af6756e7349https://doi.org/10.1186/s12986-026-01088-2
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