PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 9, 2026International Dental Journal0 citationsOpen Access

NLRP12 Alleviated Periodontal Destruction via Suppressing Nuclear Factor Kappa-B Signalling Pathway

View Full Paper
SXShuangshuang XuWWWeiping WangYSYuhui Sun

Key Points

  • Investigate NLRP12's role in inflammatory response suppression and osteogenic differentiation in periodontal tissue.
  • Examined the impact of NLRP12 on PDLSCs
  • Evaluated changes in inflammatory responses
  • Analyzed osteogenic differentiation pathways
  • NLRP12 significantly suppressed inflammatory responses
  • Enhanced osteogenic differentiation of PDLSCs was observed
  • Downregulation of the nuclear factor kappa-B pathway was confirmed

Abstract

NLRP12 suppressed inflammatory responses while enhancing osteogenic differentiation of PDLSCs via downregulating the activation of the nuclear factor kappa-B pathway, indicating that NLRP12 is a latent target for enhancing PDLSCs-based periodontal tissue regeneration.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69897983f0ec2af6756e73c6https://doi.org/10.1016/j.identj.2026.109417
Ask AI
Helpful
Bookmark
Share
View Full Paper