Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 9, 2026PLoS ONEOpen Access

Vancomycin variable Enterococci in the Netherlands (2018–2023) and the mechanism of resistance induction

View Full Paper
Ask AI
Bookmark
Share

Authors

CWChristian J. H. von WintersdorffMRMilika RoelofsenLVLinda Versteegh

Discussion

Loading...

Member takes

Overview

Analysis reveals vancomycin variable enterococci presence in the Netherlands, indicating potential for severe infections.

Key Points

  • This research aims to investigate the prevalence of vancomycin variable enterococci (VVE) and their resistance mechanisms in the Netherlands.
  • Collaborated with two Dutch clinical microbiology laboratories
  • Screened 477 enterococcal isolates using molecular assays for vancomycin resistance genes
  • Conducted genomic analysis to identify mutations in regulatory proteins
  • Six isolates carried vancomycin resistance genes but were phenotypically susceptible
  • Three of these developed vancomycin resistance in vitro after exposure
  • Identified specific mutations in van operon regulator proteins associated with resistance

Cite This Study

Wintersdorff et al. (2026) studied this question.

synapsesocial.com/papers/698979a6f0ec2af6756e77f5https://doi.org/10.1371/journal.pone.0342092
View Full Paper
Ask AI
Bookmark
Share