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February 9, 2026Proceedings of the National Academy of Sciences0 citationsOpen Access

HSCs/MPPs as Origin Cells Affecting Immune Environment in PML::RARA and CBFα/β Fusion AML

HSCs/MPPs as cells of origin with altered differentiation hierarchy impairing immunomicroenvironment in PML::RARA and CBFα/β fusion AML

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Authors

NQNiu QiaoZWZixuan WangYZYu-Liang Zhang

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Overview

Investigates altered differentiation in leukemia stem cells, affecting immune function in acute myeloid leukemia subtypes, highlighting crucial therapeutic implications.

Key Points

  • The research aims to explore how leukemia stem cells influence immune cells and differentiation hierarchies in acute myeloid leukemia.
  • Utilized single-cell RNA sequencing to analyze AML subtypes
  • Examined fusion transcription factor expression in leukemia and immune cells
  • Conducted DNA-FISH to confirm fTF presence in various cell types
  • Developed a ligand-receptor risk-scoring model for prognostics
  • Fusion transcription factors are expressed in leukemia blasts and immune cells
  • Evidence of altered immune cell communication networks linked to fTF expression
  • Identified necessity to target LSCs for effective long-term remission in AML patients

Cite This Study

Qiao et al. (2026) studied this question.

synapsesocial.com/papers/698979b9f0ec2af6756e7909https://doi.org/10.1073/pnas.2526334123
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