What question did this study set out to answer?

To evaluate the role of FAPI PET/CT scan in a pediatric patient with elevated thyroglobulin and negative iodine scintigraphy.

February 9, 2026

Elevated FAPI Activity in Lung Metastases in a Pediatric Thyroid Cancer Patient With Thyroglobulin Elevation and Negative Iodine Scintigraphy

Key Points

To evaluate the role of FAPI PET/CT scan in a pediatric patient with elevated thyroglobulin and negative iodine scintigraphy.
Conducted 18 F-FAPI PET/CT scan on a 7-year-old boy
Assessed lesions in the neck and pulmonary regions
Monitored for false-positive findings during analysis
Intense FAPI activity detected in right neck metastatic lymph node
Significant uptake observed in pulmonary metastases
Highlighted need for caution regarding false-positive FAPI findings in pediatric cases

Abstract

In adults, fibroblast activation protein inhibitor (FAPI) PET/CT scan has been employed for detecting recurrent and metastatic thyroid cancer in patients with thyroglobulin elevation and negative iodine scintigraphy (TENIS) syndrome. A 7-year-old boy with TENIS syndrome underwent 18 F-FAPI PET/CT scan, which showed intense 18 F-FAPI activity in metastatic lymph node in the right neck and pulmonary metastases. Meanwhile, intense uptake was noted on the region of the right ischiopubic synchondrosis. This case sheds light on the use of FAPI PET/CT scan in pediatric patients with TENIS. The need for caution is also highlighted for false-positive FAPI PET/CT findings in pediatric patients.

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