Identifying genome-by-childhood trauma interactions for depression using a forest-based approach in the UK Biobank and Adolescent Brain Cognitive Development Study
Analysis reveals gene-environment interactions affecting depression in UK Biobank and Adolescent Brain Cognitive Development Study, suggesting new insights into genetic risk factors.
Key Points
The aim is to investigate the interactions between genetic factors and childhood trauma in relation to depression.
Applied a forest-based machine learning approach to analyze 38,018 UK Biobank participants.
Examined interactions between 285,677 single-nucleotide polymorphisms and three types of trauma.
Identified SNP-environment pairs, focusing on the role of childhood trauma.
Found 8,225 significant SNP-environment pairs across 1,732 genes.
Stratified heritability was 13.3% in childhood trauma-exposed individuals versus 6.0% in unexposed individuals.
Thirteen top genes were replicated in the Adolescent Brain Cognitive Development Study.