ABSTRACT This paper presents advancements in manufacturing ultra‐soft hydrogel scaffolds via a high‐resolution light‐based vat‐photopolymerization technique called Continuous Liquid Interface Production (CLIP). High‐resolution scaffolds were made using a blend of natural and synthetic hydrogels to enhance printability, structural integrity, and cell‐seeding efficiency. Additionally, we demonstrate the fabrication of complex lattice‐based scaffolds and their utility for therapeutic cell loading. These studies promote the broader adoption of high‐resolution 3D printing of hydrogel scaffolds, enabling precise control over the mechanical properties and structural complexities required for next‐generation soft hydrogel‐based architected structures. These soft lattice‐based scaffolds are rationally designed for use in the delivery of cell therapies, such as therapeutic neural stem cells currently being investigated for the treatment of recurrent glioblastoma.
García‐Ávila et al. (Fri,) studied this question.