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February 10, 2026Cell Communication and Signaling0 citationsOpen Access

Protein disulfide isomerase A6 (PDIA6) is essential for acrosome biogenesis and male fertility in mice

XYXiaofeng YanYZY. M. ZhangAYAizhen Yang

Key Points

  • Investigate the role of PDIA6 in redox regulation and spermatogenesis affecting male fertility in mice.
  • Examined the function of PDIA6 in male reproduction
  • Analyzed its role in acrosome biogenesis
  • Studied redox regulation of protein synthesis
  • PDIA6 is crucial for normal sperm development
  • Disruption of PDIA6 impairs acrosome formation
  • Male mice lacking PDIA6 show infertility.

Abstract

PDIA6 is essential for redox regulation of protein synthesis and spermatogenesis causing male fertility in mice.

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Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/698acaf07c832249c30ba8a4https://doi.org/10.1186/s12964-026-02709-2
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