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Synapse
February 10, 2026

Dynamically Reprograms Mitochondrial Respiration to Augment Cuproptosis in Cancer Therapy.

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Authors

HZHaohan ZhouRWR. WangFZFang Zhu

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Overview

Demonstrates augmented cuproptosis in cancer cells via lactate oxidase delivery, suggesting new treatment strategies.

Key Points

  • This research aims to investigate how lactate oxidase aids cuproptosis by altering mitochondrial respiration and cancer cell metabolism.
  • Development of a copper-coordinated polymer for lactate oxidase delivery into cancer cells.
  • Modulation of pyruvate dehydrogenase and pyruvate kinase activities in tumor cells.
  • Analysis of mitochondrial function and initiation of cuproptosis and ferroptosis pathways.
  • Enhanced mitochondrial respiration is observed, facilitating cuproptosis.
  • Development of nanoparticles demonstrating efficient delivery and potent antitumor efficacy in vivo.
  • Activation of dihydrolipoamide S-acetyltransferase oligomerization disrupts the tricarboxylic acid cycle.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/698acaf07c832249c30ba8a8https://doi.org/10.1002/smll.202513435
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lactate metabolic reprogramming based on LOX/LDHi-Cu NP to enhance copper death in hepatocellular carcinoma cells.2026
  2. 2Nanomaterials for precise cuproptosis modulation: From molecular mechanisms to systemic therapeutics2026
  3. 3Tumor glucose reprogramming suppresses cuproptosis: A review2025 · 18 citations
  4. 4Mitochondrial‐Targeted Copper Delivery for Cuproptosis‐Based Synergistic Cancer Therapy2024 · 71 citations
  5. 5Epigenetic regulation of cuproptosis in cancer: mechanisms, microenvironment, and therapeutic implications2026