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February 11, 2026The Journal of Prevention of Alzheimer s Disease2 citationsOpen Access

Cumulative blood pressure and risk of dementia and cognitive decline: a systematic review and meta-analysis

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RWRuirui WangYGYijie GaoNENicole Ee

Key Points

  • To investigate the relationship between cumulative blood pressure and the risk of dementia and cognitive decline.
  • Conducted a systematic review and meta-analysis of existing studies on cumulative blood pressure.
  • Analyzed data on incident dementia and cognitive decline associated with cumulative systolic and diastolic blood pressure.
  • Recommended future studies to include age-stratified analyses and additional blood pressure metrics.
  • Higher cumulative systolic blood pressure is linked to an increased risk of dementia and cognitive decline.
  • Findings on cumulative diastolic blood pressure associations are inconsistent.
  • Call for more comprehensive studies to evaluate the effects of other blood pressure measures.

Abstract

Higher cSBP is associated with increased risk of incident dementia and cognitive decline, whereas associations for cDBP are mixed. Given the limited evidence, future studies should incorporate age-stratified analyses and consider including cumulative pulse pressure and mean arterial pressure to further clarify the relationship between cBP and cognition.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/698c1c33267fb587c655e726https://doi.org/10.1016/j.tjpad.2026.100500
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Also Consider

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