What question did this study set out to answer?

The aim is to review the significant advancements in RNA-based therapies and their impact on modern medicine.

February 11, 2026npj Drug Discovery.8 citationsOpen Access

Advancements in RNA-based therapies from bench to bedside

ASAmrita Singh MTMuktika Tekade SNSreeharsha Nagaraja

Puntos clave

The aim is to review the significant advancements in RNA-based therapies and their impact on modern medicine.
Review of key milestones in RNA therapy innovations
Analysis of various RNA-based technologies including mRNA and aptamers
Evaluation of delivery technologies and clinical approvals
Highlighted the success of COVID-19 mRNA vaccines as a benchmark
Identified ongoing trials shaping the future of RNA therapies
Showcased advancements in targeted treatment approaches for diverse diseases

Resumen

Abstract RNA research has advanced rapidly, becoming a key component of modern therapeutics. This review outlines key milestones and innovations from antisense oligonucleotides and RNA interference to mRNA therapies and aptamers that have enabled targeted treatments for diverse diseases. The success of COVID-19 mRNA vaccines highlighted the remarkable clinical potential of RNA-based technologies. Emphasis is placed on delivery technologies, landmark approvals, and ongoing trials shaping the future of RNA-based medicine.

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