Female gender was associated with higher cerebral vasomotor reactivity to L-arginine compared to males in type 1 diabetes (20.1% vs. 14.6%, p<0.01), independent of age and disease course.
Cross-Sectional (n=49)
Does female gender improve cerebrovascular reactivity to L-arginine compared to male gender in middle-aged patients with type 1 diabetes?
Middle-aged females with type 1 diabetes exhibit greater cerebral vasomotor reactivity to L-arginine compared to males, suggesting a protective effect of female gender on cerebral endothelial function.
Absolute Event Rate: 20.1% vs 14.6%
p-value: p=<0.01
Type 1 diabetes (T1D) increases the risk for cerebral microangiopathy. However, the association between gender and cerebral microcirculatory dysfunction in T1D remains undetermined. Therefore, we have conducted a comparative analysis of cerebral endothelial-mediated microcirculatory parameters between middle-aged Caucasian females and males with type 1 diabetes. The present study examined the nitric oxide-induced vasomotor reactivity of middle cerebral arteries (MCA using transcranial Doppler and L–arginine infusion (L–arg VMR)). The study compared L–arg VMR between 23 males and 26 females with type 1 diabetes without a history of overt cerebrovascular disease. Mean L–arg VMR and baseline MCA flow velocity (V rest) were higher in females than in males (20.1 ± 5.4 vs. 14.6 ± 7.1% p < 0.01 and 73, 54–106 vs. 60.7–77 cm/s p < 0.01, respectively). Males were older than females (39.7 range: 31.3–55.7 vs. 36.5 range: 25.0–45.5 years, p = 0.02) and were characterized by later T1D onset and higher insulin/24 h, triglyceride levels and body mass index (BMI). Higher L–arg VMR in females persisted when co-variated with patients’ age, age of onset, BMI, triglyceride level and V rest. Cerebral vasomotor reactivity to L–arginine showed greater efficacy in middle-aged females than in males with T1D, independent of age and disease course. The protective effect of the female gender on cerebral endothelium function has been demonstrated in type 1 diabetes.
Kozera et al. (Mon,) conducted a cross-sectional in Type 1 diabetes (n=49). Female gender vs. Male gender was evaluated on Mean L-arginine-induced vasomotor reactivity (L-arg VMR) (p=<0.01). Female gender was associated with higher cerebral vasomotor reactivity to L-arginine compared to males in type 1 diabetes (20.1% vs. 14.6%, p<0.01), independent of age and disease course.