Ciprofol reduced the incidence of post-induction hypotension by 29.1% compared to propofol (36.4% vs. 65.5%, p=0.002) in elderly patients undergoing total hip arthroplasty.
Observational (n=110)
No
Does ciprofol reduce the incidence of post-induction hypotension compared to propofol in elderly patients undergoing total hip arthroplasty?
Ciprofol significantly reduces the incidence of post-induction hypotension and injection pain compared to propofol in elderly patients undergoing total hip arthroplasty, offering improved hemodynamic stability.
Effect estimate: ARR 29.1% (95% CI 11.2%–47.0%)
Absolute Event Rate: 36.4% vs 65.5%
p-value: p=0.002
Objective Post-induction hypotension (PIH) represents a frequent perioperative complication among elderly patients, and its prevention is critical for reducing organ damage and postoperative adverse outcomes. This study aims to evaluate the impact of ciprofol on the incidence of PIH when used for general anesthesia induction in elderly patients. Methods A retrospective review was carried out on the clinical records of elderly patients who underwent elective total hip replacement surgery at our hospital between August 2024 and July 2025. Patients were stratified into the ciprofol group and the propofol group based on the anesthetic sedative agents administered. The primary outcome indicator was PIH, characterized as a mean arterial pressure (MAP) ≤65 mmHg or a reduction greater than 30% relative to baseline values within 20 min post-induction. Subgroup analyses included considerations of preoperative hypertension, the Clinical Frailty Scale (CFS), the age-adjusted Charlson Comorbidity Index (aCCI), and patient age. Results Baseline clinical features were comparable across groups. The incidence of PIH was markedly lower in the ciprofol group than in the propofol group (36.4% vs. 65.5%; absolute risk reduction = 29.1, 95% confidence interval: 11.2–47.0%, p = 0.002). Subgroup analyses demonstrated that the advantages of ciprofol remained consistent across all pre-specified subgroups, with prominent differences noted in patients aged under 90 years, those with an aCCI of ≤4, a CFS score of ≤4, and baseline blood pressure (BP) of 140/90 mmHg. Conclusion Ciprofol reduces PIH risk, improves haemodynamic stability, and decreases vasoactive agent use and injection pain compared with propofol in elderly patients, independent of baseline characteristics, indicating suitability for anesthetic management in this population.
Zhu et al. (Mon,) conducted a observational in Elderly patients (≥65 years) undergoing elective total hip arthroplasty under general anesthesia with ASA physical status I-III and BMI 18-30 kg/m2 (n=110). ciprofol vs. propofol 2.0 mg·kg−1 intravenous slow infusion over 60 seconds for induction; maintenance dose 4–6 mg·kg−1·h−1 was evaluated on Incidence of post-induction hypotension defined as mean arterial pressure (MAP) ≤65 mmHg or >30% reduction from baseline within 20 min post-induction or before surgery start (ARR 29.1%, 95% CI 11.2%–47.0%, p=0.002). Ciprofol reduced the incidence of post-induction hypotension by 29.1% compared to propofol (36.4% vs. 65.5%, p=0.002) in elderly patients undergoing total hip arthroplasty.