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February 12, 2026Discover Oncology0 citationsOpen Access

JAG1 expression in papillary thyroid cancer stem-like cells predicts poor prognosis and implicates angiogenesis

RYRiho Yoshida-MinatoTHTetsuhiro HorieMAMitsuharu Aga

Key Points

  • To investigate the gene expression profile of thyroid cancer stem-like cells and their tumor interactions.
  • Analyzed gene expression profiles of thyroid cancer stem-like cells
  • Examined the role of JAG1 in tumor progression
  • Assessed interactions between cancer stem-like cells and tumor microenvironment
  • JAG1 expression correlates with poor prognosis in papillary thyroid cancer
  • Thyroid cancer stem-like cells exhibit increased angiogenic potential
  • Interactions with tumor tissue cells influence cancer progression

Abstract

This study provides new insights into the gene expression profile of thyroid CSC-like cells and their interactions with cells constituting tumor tissues.

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Cite This Study

Yoshida-Minato et al. (2026) studied this question.

synapsesocial.com/papers/698d6d445be6419ac0d52354https://doi.org/10.1007/s12672-026-04601-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive analysis of the papillary thyroid carcinoma identifies CSGALNACT1 as a proliferation driver and prognostic biomarker2025
  2. 2Tumor cell Jagged-1 promotes regional lymphatic metastasis and predicts recurrence in node-positive breast cancer2026
  3. 3Targeting DEP domain containing 1 in anaplastic thyroid carcinoma: Implications for stemness regulation and malignant phenotype suppression2024 · 1 citations
  4. 4Identification and validation of a prognostic anoikis-related gene signature in papillary thyroid carcinoma by integrated analysis of single-cell and bulk RNA-sequencing2024 · 1 citations
  5. 5Single nuclei and spatial transcriptomes suggest a stratification of papillary and anaplastic thyroid cancer cells2024 · 1 citations