Surrogate insulin resistance indices were independently associated with hypertension, with each 1 SD increase in METS-IR linked to 52.5% higher odds of hypertension, and TyG index linked to 23.4% higher odds, in Iranian adults aged 35-65.
Cross-Sectional (n=9,438)
No
Are elevated surrogate insulin resistance indices (TyG, Tg/HDL-c, METS-IR, CHG) associated with higher odds of hypertension in adults?
Surrogate insulin resistance indices, particularly METS-IR and TyG, are independently associated with hypertension and may help identify individuals with early cardiometabolic risk.
Estimación del efecto: OR 1.234 per 1 SD increase in TyG; OR 1.081 per 1 SD increase in Tg/HDL-c; OR 1.525 per 1 SD increase in METS-IR; OR 1.099 per 1 SD increase in CHG
valor p: p=<0.001 for all indices
Surrogate IR indices were independently associated with hypertension, reflecting underlying metabolic dysfunction linked to blood pressure elevation. These markers may complement traditional assessments by helping to identify individuals with early or latent cardiometabolic risk.
Tajik et al. (Mon,) conducted a cross-sectional in Adults aged 35-65 years in northeastern Iran from the MASHAD cohort, assessed for hypertension (n=9,438). Surrogate insulin resistance indices (TyG, Tg/HDL-c, METS-IR, CHG) vs. No insulin resistance surrogate indices (baseline risk) was evaluated on Association of surrogate insulin resistance indices with prevalence of hypertension (defined as BP ≥140/90 mmHg or use of antihypertensive medication) (OR 1.234 per 1 SD increase in TyG; OR 1.081 per 1 SD increase in Tg/HDL-c; OR 1.525 per 1 SD increase in METS-IR; OR 1.099 per 1 SD increase in CHG, p=<0.001 for all indices). Surrogate insulin resistance indices were independently associated with hypertension, with each 1 SD increase in METS-IR linked to 52.5% higher odds of hypertension, and TyG index linked to 23.4% higher odds, in Iranian adults aged 35-65.