What question did this study set out to answer?

To assess the impact of Lactiplantibacillus plantarum on cholesterol levels in individuals with moderate dyslipidemia while considering gut microbiota and host genetics.

February 12, 2026npj Science of Food2 citationsOpen Access

Effects of Lactiplantibacillus plantarum on moderate dyslipidemia before medication involving gut microbiota and host genetics

GMGuoqing Ma YLYunfeng Li CHChen He

Key Points

To assess the impact of Lactiplantibacillus plantarum on cholesterol levels in individuals with moderate dyslipidemia while considering gut microbiota and host genetics.
Conducted a 12-week trial with 136 participants suffering from moderate dyslipidemia.
Random assignment to Lactiplantibacillus plantarum supplementation or placebo.
Analysis of LDL-C and total cholesterol levels pre- and post-intervention.
Utilized machine learning models to evaluate the relationship between microbiota changes and lipid reductions.
LP supplementation resulted in significant reductions in LDL-C (-0.118 mmol/L) and total cholesterol (-0.163 mmol/L) compared to placebo.
Participants with lower genetic risk scores showed substantial LDL-C reductions (-0.749 ± 0.632 mmol/L) and total cholesterol reductions (-1.306 ± 0.436 mmol/L).
Post-intervention differences in gut microbial composition correlated with lipid changes, especially in bile acids.

Abstract

In this 12-week trial, 136 participants with moderately dyslipidemia were randomly assigned to receive Lactiplantibacillus plantarum (LP) or placebo. In the intention-to-treat analysis, the group-by-time interaction did not reach statistical significance. However, in per-protocol set (adherence ≥85% and no antibiotic use), LP supplementation reduced low-density lipoprotein cholesterol (LDL-C) (-0.118 mmol/L) and total cholesterol (TC) (-0.163 mmol/L), compared with the placebo (both Pgroup×time trend and Pinteraction < 0.001). Our data supported the beneficial effects of LP in patients with moderate dyslipidemia involving gut microbiota and host genetics.

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Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/698d6d445be6419ac0d5238c https://doi.org/10.1038/s41538-026-00749-z

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February 12, 2026npj Science of Food2 citationsOpen Access

Effects of Lactiplantibacillus plantarum on moderate dyslipidemia before medication involving gut microbiota and host genetics

GMGuoqing Ma YLYunfeng Li CHChen He

Key Points

To assess the impact of Lactiplantibacillus plantarum on cholesterol levels in individuals with moderate dyslipidemia while considering gut microbiota and host genetics.
Conducted a 12-week trial with 136 participants suffering from moderate dyslipidemia.
Random assignment to Lactiplantibacillus plantarum supplementation or placebo.
Analysis of LDL-C and total cholesterol levels pre- and post-intervention.
Utilized machine learning models to evaluate the relationship between microbiota changes and lipid reductions.
LP supplementation resulted in significant reductions in LDL-C (-0.118 mmol/L) and total cholesterol (-0.163 mmol/L) compared to placebo.
Participants with lower genetic risk scores showed substantial LDL-C reductions (-0.749 ± 0.632 mmol/L) and total cholesterol reductions (-1.306 ± 0.436 mmol/L).
Post-intervention differences in gut microbial composition correlated with lipid changes, especially in bile acids.

Abstract

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Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/698d6d445be6419ac0d5238c https://doi.org/10.1038/s41538-026-00749-z

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