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The research aims to develop an efficient copper-catalyzed method for enantioconvergent coupling of alkylboronic esters.

February 12, 2026Journal of the American Chemical Society0 citations

Copper-Catalyzed Enantioconvergent Deborylative Coupling of Benzylboronic Esters

Copper-Catalyzed Enantioconvergent Radical Deborylative Coupling of Racemic Benzylboronic Esters with Alkynes and Alkenylboronic Esters

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Authors

ZGZeng Gao DXDong-Dong Xu LFLiwen Fan

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Overview

This research demonstrates a novel copper-catalyzed method to form chiral C-C bonds, indicating high effectiveness in diverse chemical environments.

Key Points

The research aims to develop an efficient copper-catalyzed method for enantioconvergent coupling of alkylboronic esters.
Utilized copper with chiral multidentate N,N,P-ligand for catalytic processes.
Implemented a radical strategy that enables boron abstraction to generate prochiral radicals.
Explored coupling reactions with both alkynes and alkenylboronic esters.
Established a new method for C(sp3)-C(sp) coupling of benzylboronic esters.
Demonstrated high chemo- and enantioselectivity in the reactions.
Showed tolerance to various functional groups and rapid reaction progress with low catalyst loading.

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Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/698d6d695be6419ac0d5253d https://doi.org/10.1021/jacs.5c21668

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February 12, 2026Journal of the American Chemical Society0 citations

Copper-Catalyzed Enantioconvergent Deborylative Coupling of Benzylboronic Esters

Copper-Catalyzed Enantioconvergent Radical Deborylative Coupling of Racemic Benzylboronic Esters with Alkynes and Alkenylboronic Esters

View Full Paper

Authors

ZGZeng Gao DXDong-Dong Xu LFLiwen Fan

Discussion

Member takes

Overview

This research demonstrates a novel copper-catalyzed method to form chiral C-C bonds, indicating high effectiveness in diverse chemical environments.

Key Points

The research aims to develop an efficient copper-catalyzed method for enantioconvergent coupling of alkylboronic esters.
Utilized copper with chiral multidentate N,N,P-ligand for catalytic processes.
Implemented a radical strategy that enables boron abstraction to generate prochiral radicals.
Explored coupling reactions with both alkynes and alkenylboronic esters.
Established a new method for C(sp3)-C(sp) coupling of benzylboronic esters.
Demonstrated high chemo- and enantioselectivity in the reactions.
Showed tolerance to various functional groups and rapid reaction progress with low catalyst loading.

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Helpful

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View Full Paper

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/698d6d695be6419ac0d5253d https://doi.org/10.1021/jacs.5c21668

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