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February 12, 2026Vox Sanguinis0 citations

From pH to glucose: Implementing a simple point‐of‐care method for platelet quality control

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BVBelén del Valle VeraMVMaría‐Jesús VayáHSHéctor Sarmiento

Key Result

A point-of-care glucometer provided reliable glucose measurements in PAS-E platelet concentrates, comparable to a standard autoanalyser on day 6 (mean difference 0.4 ± 2.6 mg/dL, p=0.415).

Key Points

  • The study aimed to evaluate the feasibility of a point-of-care glucometer for measuring glucose in stored platelet concentrates.
  • Analyzed thirty platelet concentrates stored in platelet additive solutions on days 2 and 6.
  • Used a point-of-care glucometer and a reference laboratory autoanalyser for comparison.
  • Conducted statistical testing, categorical analysis, and correlation analysis.
  • Glucose levels from both methods were comparable on day 6.
  • Mean difference was 2.2 ± 5.5 mg/dL on day 2 and 0.4 ± 2.6 mg/dL on day 6.
  • Strong linear association observed with r = 0.988 and p < 0.001.

Structured PICO

Does a point-of-care glucometer provide reliable glucose measurements in PAS-E stored platelet concentrates compared to a standard laboratory autoanalyser?

P
Population
30 platelet concentrates (PCs) suspended in platelet additive solution (PAS-E)
I
Intervention
Glucose measurement using a point-of-care (POC) glucometer (Accu-Chek Instant®, Roche)
C
Comparator
Glucose measurement using a reference laboratory autoanalyser (AU5800, Beckman Coulter®)
O
Outcome
Comparability of glucose measurements between the POC glucometer and the reference autoanalyser on days 2 and 6 of storagesurrogate

A point-of-care glucometer provides reliable glucose measurements in PAS-E platelet concentrates, offering a simple and cost-effective method to implement new EDQM quality control recommendations.

Main Result

Effect estimate: Mean difference 0.4 mg/dL

p-value: p=0.415

Abstract

Abstract Background and Objectives The 21st edition of the European Directorate for the Quality of Medicines p < 0.001), correlation was not interpreted as evidence of analytical agreement. Classification of samples below the clinically relevant threshold of 10 mg/dL (≈0.56 mmol/L) did not differ significantly between methods. Conclusion A POC provides reliable glucose measurements in PAS‐E PCs, comparable to a standard autoanalyser. This simple, rapid and cost‐effective approach may facilitate implementation of the new EDQM recommendation and improve QC efficiency in BE.

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Cite This Study

Vera et al. (2026) studied Platelet concentrates stored in platelet additive solutions (n=30). Point-of-care (POC) glucometer (Accu-Chek Instant) vs. Reference laboratory autoanalyser (AU5800) was evaluated on Glucose measurement comparison on day 6 (Mean difference 0.4 mg/dL, p=0.415). A point-of-care glucometer provided reliable glucose measurements in PAS-E platelet concentrates, comparable to a standard autoanalyser on day 6 (mean difference 0.4 ± 2.6 mg/dL, p=0.415).

synapsesocial.com/papers/698d6de45be6419ac0d5318chttps://doi.org/10.1111/vox.70211
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