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February 12, 2026SmartBotOpen Access

Designer DNA‐Based Machines

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Authors

YAY. AnFWFan WuYXYanyu Xiong

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Overview

This review discusses designer DNA-based machines' principles, applications, and future perspectives, indicating a transformation in biotechnology.

Key Points

  • The aim is to explore the design, analysis, and applications of DNA-based machines within bionanotechnology and mechanical engineering.
  • Reviewed existing literature on DNA-based machines
  • Analyzed design and fabrication strategies
  • Evaluated applications in biomedicine and nanomanufacturing
  • Provided perspectives on AI integration in development
  • Outlined the evolution from DNA motifs to dynamic robots
  • Identified critical components for complex DNA machine construction
  • Highlighted trade-offs in design accuracy and computational efficiency
  • Discussed applications in precision medicine and atomic-scale manufacturing
  • Emphasized potential for AI-enhanced design and autonomous fabrication

Cite This Study

An et al. (2026) studied this question.

synapsesocial.com/papers/698d6e055be6419ac0d535e6https://doi.org/10.1002/smb2.70029
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nucleic Acid‐Based Molecular Machines for Biological Applications2025
  2. 2The motive forces in DNA-enabled nanomachinery2024 · 3 citations
  3. 3DNA-Based Molecular Machines: Controlling Mechanisms and Biosensing Applications2024 · 1 citations
  4. 4Designing DNA Nanostructures: Principles, Strategies, and Applications2026
  5. 5Designing DNA Nanostructures: Principles, Strategies, and Applications2026