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February 12, 2026Organic & Biomolecular Chemistry0 citations

Synthesis of α-trifluoromethyl-β-lactams via copper-catalyzed Kinugasa reaction of nitrones with 3,3,3-trifluoropropyne and their defluorination

SCShouxiong ChenPYPeiqi YangBHBiqiong Hong

Key Points

  • To develop an efficient method for synthesizing α-trifluoromethyl-β-lactams using nitrones and copper catalysis.
  • Utilized copper-catalyzed Kinugasa reaction of nitrones
  • Employed in situ generated 3,3,3-trifluoropropyne
  • Characterized regioselectivity in product formation
  • Successfully synthesized α-trifluoromethyl-β-lactams
  • Demonstrated the efficiency of the copper-catalyzed process
  • Observed regioselective reactions yielding desired products

Abstract

An efficient protocol for synthesizing α-trifluoromethyl-β-lactams through copper-catalyzed Kinugasa reaction of nitrones with in situ generated 3,3,3-trifluoropropyne. The reaction proceeds through generations the Cu(I) acetylide species, followed by a regioselective...

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/698d6e055be6419ac0d53702https://doi.org/10.1039/d5ob01913c
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