Cavernous malformations of the corpus callosum are rare accounting for less than 1% of all subtentorial cavernous malformations. Clinical manifestations are usually caused by hemorrhage into adjacent parenchyma. Epileptic seizures are the most common. Multiple hemorrhages with progressive neurological impairment require surgical intervention. Objective. To present giant cavernoma of the genu of the corpus callosum extending to the fornix, basal frontal lobes and bottom of the third ventricle, as well as review of available literature. Results. A patient with giant cavernous malformation of the genu of the corpus callosum extending to the fornix, basal frontal lobes and bottom of the third ventricle underwent total resection of malformation. Symptoms included headaches, epileptic seizures, and hydrocephalus. Korsakoff syndrome developed after surgery and partially regressed at discharge. After 3 months, hydrocephalus completely regressed. Elements of Korsakoff syndrome persisted with improvements under rehabilitation sessions with neuropsychologist. Conclusion. Despite difficult anatomical location and giant size, total resection of cavernous malformation provided satisfactory outcome with minimal neurological complications.
Chizhova et al. (2026) studied this question.