Vitamin D and Its Phyto-Derived Mimetics Ameliorate Vertigo and Associated Systemic Disorders:

Four case reports are presented which may underline the useful role of vitamin D3 receptor agonists/mimetics and non-addictive flumazenil-insensitive GABAergic enhancers in the management of central and peripheral vertigo. · Turmeric, lemon-ginger and black pepper teas; · chamomile, strawberry and green teas; · rosemary, chamomile teas + tadalafil; · turmeric, strawberry teas + vitamin D3 were administered to 1-4 patients respectively. Their effect on vertigo/dizziness, infection incidence, MMSE, and other selected neuro-cardio-metabolic parameters were assessed at 3 and 6 months. Although all the treatments had noted significant effects, the 4th treatment most significantly (DMR) at 6-months (P < 0.05) reduced BMI, mean arterial pressure (MAP), FBS, total cholesterol, LDL-C, triglycerides, perceived stress scale (PSS) score, dizziness handicap inventory (DHI) score; and most significantly increased HDL-C, 10-item Connors-Davidson resilience score and visual acuity, with improvement in MMSE accompanied with decreased incidence of URTIs. With increased stress, ageing and central nervous pathologies, there may be decrease of vitamin D receptor responsiveness coupled with depreciation of the GABAergic/glutamatergic ratio. This imbalance of inhibitory- to -excitatory coupling is known to be a causative factor in vertigo/dizziness, and neurodevelopmental/neuropsychiatric/neurodegenerative diseases. Tea forms of phyto-derived GABAergic enhancers or vitamin D3-mimetics which are safe and non-addictive with or without vitamin D supplementation upregulate the VDR-GABA-NO-cGMP-PKG pathway and may prove to be additive to present agents for treatment not only of vertigo but also for attenuation of endothelial-/neuronal dysfunction - mediated aetiologically-confounding systemic disorders crucial in vertigo causation. These mediators of the pro-survival VDR- GABA-eNOS-cGMP-PKG signalling pathway may be the ‘GABA therapy’ and ‘fountain of youth’/’dew of youth’ restorative for their unique role in whole body- homeostasis that is dependent on an efficient brain-organ interaction implicated in regulation of the neuro-endocrine-immune-metabolic network; and thus deserve compelling attention.