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February 12, 2026RSC Chemical Biology0 citationsOpen Access

Tuning Potency for Precision: The Role of the G4-Ligand in G4-Ligand-Conjugated Oligonucleotides Targeting Individual G-Quadruplex DNA Structures

AAAlva AbrahamssonSKSakina KhwajaABAndreas Berner

Key Points

  • The study aims to explore how G4-ligands can be used to precisely target G-quadruplex DNA structures in gene-regulatory regions.
  • Analyzed the binding affinity of G4-ligands to G-quadruplex DNA
  • Developed oligonucleotides conjugated with G4-ligands
  • Utilized biochemical assays to measure stabilization effects
  • G4-ligands increased binding to G-quadruplex structures significantly
  • Conjugated oligonucleotides showed enhanced specificity for target regions
  • Stabilization of G4 DNA resulted in altered gene expression profiles

Abstract

The non-B DNA secondary structure known as G-quadruplex (G4) DNA can form in gene-regulatory regions of the human genome. Organic small molecules, so called G4-ligands, which bind and stabilize G4...

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Cite This Study

Abrahamsson et al. (2025) studied this question.

synapsesocial.com/papers/698d6e7b5be6419ac0d544d1https://doi.org/10.1039/d5cb00302d
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