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February 12, 2026Journal of Advanced Pharmaceutical Technology amp Research0 citationsOpen Access

Lercanidipine's Nephroprotective Role Against Gentamicin-Induced Kidney Damage

Nephroprotective effect of lercanidipine against gentamicin-induced kidney damage

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Authors

MSMaryam H. ShubbarHKHussam Kadhum

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Overview

Experimental evaluation shows lercanidipine improves kidney function in rats affected by gentamicin, indicating protective benefits.

Key Points

  • This research aims to assess the protective effects of lercanidipine against kidney damage caused by gentamicin.
  • Divided adult Sprague–Dawley rats into four groups: control, lercanidipine, gentamicin, and a combination group.
  • Administered lercanidipine (3 mg/kg/day) and gentamicin (50 mg/kg/day) for 5 days.
  • Evaluated serum levels of urea, creatinine, sodium, and potassium, along with oxidative stress markers in kidney homogenates.
  • Gentamicin caused significant renal dysfunction with elevated serum urea and creatinine levels.
  • Co-treatment with lercanidipine improved electrolyte balance, reducing sodium by 20% and increasing potassium by 27%.
  • Lercanidipine reduced malondialdehyde levels by about 65% and enhanced superoxide dismutase and glutathione activities.
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Cite This Study

Shubbar et al. (2026) studied this question.

synapsesocial.com/papers/698d6e925be6419ac0d54669https://doi.org/10.4103/japtr.japtr_243_25
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