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February 12, 2026Investigative Ophthalmology & Visual Science0 citationsOpen Access

Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma

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MDMichaela DunnGCGrant CullJRJuan Reynaud

Key Points

  • This research aims to investigate the progression of microvascular volume loss compared to nerve fiber layer and neuroretinal rim tissue loss in glaucoma.
  • Evaluated nonhuman primate models of experimental glaucoma
  • Assessed microvasculature within the RNFL
  • Monitored progression of both microvascular and tissue loss
  • Microvascular volume loss occurs early in glaucoma progression
  • Loss of microvasculature exceeds the loss of nerve fiber layer
  • Neuroretinal rim tissue loss does not match microvascular loss rate

Abstract

Progressive loss of functional microvasculature (adequately perfused capillaries) within the RNFL, occurring early and in excess of the neuroglial tissue it supplies, supports future investigation of therapeutic strategies that target vascular function.

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Cite This Study

Dunn et al. (2026) studied this question.

synapsesocial.com/papers/698d6ebb5be6419ac0d54700https://doi.org/10.1167/iovs.67.2.24
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