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February 12, 2026European Journal of NeurologyOpen Access

Associated Autoimmunity in Myasthenia Gravis in Denmark: A Nationwide Case–Control Study

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Authors

JNJosefine Jul Jarbæk NielsenLLLotte LevisonHAHenning Andersen

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Overview

A case–control study observes autoimmunity associations in myasthenia gravis patients, implying shared risks.

Key Points

  • This study investigates the relationship between myasthenia gravis (MG) and other autoimmune diseases (ADs).
  • Nationwide, population-based case–control study conducted from 1985 to 2020.
  • Matched 2110 MG patients with 21,100 controls by age, sex, and index date.
  • Used conditional logistic regression for estimating odds ratios for AD diagnoses prior to MG.
  • Applied Cox regression to assess hazard ratios for AD diagnoses after MG.
  • 5.2% of MG patients had an AD diagnosis before onset, compared to 2.7% of controls (OR 1.9).
  • 5.0% of MG patients received an AD diagnosis after MG, compared to 2.7% of controls (HR 2.1).
  • Stronger associations were noted particularly in females and those ≤ 50 years.
  • Autoimmune thyroiditis, systemic lupus erythematosus, and pernicious anemia showed the strongest links.

Cite This Study

Nielsen et al. (2026) studied this question.

synapsesocial.com/papers/698d6eca5be6419ac0d54908https://doi.org/10.1111/ene.70498
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