What question did this study set out to answer?

This research aims to develop and validate a prognostic model for lung adenocarcinoma based on oxidative phosphorylation (OXPHOS).

February 13, 2026Discover Oncology0 citationsOpen Access

Development and validation of an oxidative phosphorylation based prognostic model revealing tumor progression and immune microenvironment in lung adenocarcinoma

HMHongxia MaXinjiang Medical University SZShaoshan ZengFujian Medical University CXChangping XieBeibu Gulf University

Key Points

This research aims to develop and validate a prognostic model for lung adenocarcinoma based on oxidative phosphorylation (OXPHOS).
Development of a prognostic model using OXPHOS data
Validation of the model with lung adenocarcinoma samples
Identification of UQCC3 and RAB5IF involvement in tumor cells
The OXPHOS-based model correlates with tumor progression
UQCC3 and RAB5IF are associated with increased malignancy
The study identifies potential biomarkers and therapeutic targets for personalized treatments

Abstract

We present an OXPHOS-based prognostic model for LUAD. OXPHOS reprogramming, particularly involving UQCC3 and RAB5IF in epithelial cells, may promote malignant proliferation and immunosuppression. These findings provide novel prognostic biomarkers and potential therapeutic targets, which may support personalized treatment strategies and guide future translational studies.

Ask AI

Helpful

Bookmark

View Full Paper