High expression of ACTL8 was identified as an independent prognostic risk factor for poor overall survival (HR 1.177) in patients with endometrial cancer.
Observational (n=623)
An insulin resistance-related 10-gene signature, particularly ACTL8, serves as a prognostic predictor and immune-related biomarker for risk stratification in endometrial cancer.
Estimación del efecto: HR 1.177 (95% CI 1.043-1.329)
valor p: p=0.0084
Our findings suggest that there are common molecular profiles between IR and EC. IR-related prognostic model represents an excellent prognosis predictor and immune-related biomarker, which can be applied to risk stratification and precise treatment of EC patients with IR.
Lu et al. (Wed,) conducted a observational in Endometrial cancer and Insulin resistance (n=623). High ACTL8 expression (part of a 10-gene signature) vs. Low ACTL8 expression was evaluated on Overall survival (independent prognostic value of ACTL8) (HR 1.177, 95% CI 1.043-1.329, p=0.0084). High expression of ACTL8 was identified as an independent prognostic risk factor for poor overall survival (HR 1.177) in patients with endometrial cancer.