Development of the synthetic route to 5-hydroxymethyl tolterodine, a key synthetic intermediate of Toviaz, via an organic solvent-free Rh-catalyzed asymmetric 1,4-addition

Puntos clave

• The aim is to develop a more efficient synthetic route to 5-hydroxymethyl tolterodine, a key intermediate of Toviaz.
• Developed an organic solvent-free protocol
• Utilized rhodium as a catalyst
• Implemented asymmetric 1,4-addition techniques
• Significantly improved yield of 5-hydroxymethyl tolterodine
• Reduced environmental impact by eliminating organic solvents
• Enhanced reaction efficiency compared to previous methods