Each 5% increase in 10-year PREVENT risk in testicular cancer survivors increased CVD odds by 2.94-fold; intermediate-high risk (≥7.5%) had 12.11-fold higher odds.
Does the AHA's 2024 PREVENT-equation predict incident cardiovascular disease in long-term testicular cancer survivors?
The AHA's 2024 PREVENT equation effectively identifies high-risk testicular cancer survivors for incident cardiovascular disease, highlighting the importance of physical activity as a modifiable risk factor.
Tasa de eventos absoluta: 0% vs 0%
Abstract Testicular cancer survivors (TCS) experience excess cardiovascular disease (CVD) incidence and mortality. To address the urgent need for new risk prediction tools, we evaluated the AHA’s 2024 PREVENT-equation among 1,759 TC survivors (TCS; median baseline age = 37 years). Baseline median 10- and 30-year CVD risks were 1.3% and 9.1%. Among evaluated survivors with follow-up (N = 737; median age = 45), each 5% increase in 10-year PREVENT risk conferred 2.94-fold odds (95%CI = 1.99–4.35, P .001) of incident CVD. Those with 10-year PREVENT absolute risk defined as intermediate-high (≥7.5% per AHA) had 12.11-fold higher odds (P .001). Associations were strongest after four cycles of etoposide/cisplatin (EPX4) (OR = 4.93, P .001), possibly driven by lower eGFR and slightly older age (P .001 each), and among TCS without vigorous baseline physical-activity (OR = 4.25, P .001). EPX4 patients were among those less engaged in activity (P = .005). PREVENT equations, utilizing routine measures, can identify high-risk TCS, highlighting physical-activity as a key modifiable factor for early intervention.
Kerns et al. (Fri,) reported a other. Each 5% increase in 10-year PREVENT risk in testicular cancer survivors increased CVD odds by 2.94-fold; intermediate-high risk (≥7.5%) had 12.11-fold higher odds.