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February 16, 2026Communications BiologyOpen Access

A two-step actin-mediated strategy enables Campylobacter jejuni to promote mitochondrial aggregation and iron homeostasis, for intracellular survival and persistence

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Authors

FNFauzy NasherBWBrendan W. Wren

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Overview

Biphasic actin-remodelling improves mitochondrial interaction and iron homeostasis in C. jejuni, suggesting pathogenesis mechanisms.

Key Points

  • This research aims to unveil the mechanisms by which Campylobacter jejuni adapts intracellularly for persistence.
  • Hypothesized a biphasic actin-remodelling strategy using CiaI and CiaD
  • Utilized dual proteomics, microscopy, and biochemical assays
  • Examined defined genetic mutants to assess actin polymerization's role
  • Actin polymerization and CiaI are critical for mitochondrial interaction
  • CiaI acts as a molecular switch by binding nucleotides with cooperative kinetics
  • Iron chelation promotes bacterial survival, indicating oxidative stress as a host defense mechanism

Cite This Study

Nasher et al. (2026) studied this question.

synapsesocial.com/papers/699264d1eb1f82dc367a0a62https://doi.org/10.1038/s42003-026-09713-9
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