Abstract Deep tissue and bloodstream yeast infections are associated with poor outcomes due to rapid progression, antifungal resistance, and immune evasion. Differentiating between wound contamination and true fungal infection remains a clinical challenge, with limited guidance on the use of prophylactic antifungal therapy in this setting. This article presents a rare case of an immunocompetent patient who sustained a degloving hand injury and radius fracture from a bread kneading machine, with subsequent deep tissue cultures growing Saccharomyces cerevisiae . The case underscores the potential risk of fungal infection in occupational injuries involving dough and emphasizes the importance of early identification and consideration of prophylactic antifungal treatment in similar scenarios.
Stefani et al. (2026) studied this question.