Astragaloside IV protects against myocardial infarction by modulating multiple pathways related to anti-inflammation, anti-oxidation, antifibrosis, and mitochondrial homeostasis.
Astragaloside IV (AS-IV)
Astragaloside IV demonstrates multifaceted protective mechanisms against myocardial infarction in experimental models, highlighting its potential as a future therapeutic strategy pending clinical validation.
Myocardial infarction (MI) is a severe cardiovascular disorder characterized by an irreversible myocardial necrosis caused by acute ischemia. The typical manifestations of MI include persistent substernal chest pain, dyspnea, nausea, vomiting, and diaphoresis. Astragaloside IV (AS-IV), a major bioactive component of Astragalus membranaceus, has been extensively investigated over the past decade. Evidence indicates that AS-IV exerts multifaceted protective effects against MI by modulating various key signaling pathways involved in anti-inflammatory, anti-oxidative stress, and antifibrotic activities, the inhibition of cardiomyocyte apoptosis, and the maintenance of mitochondrial homeostasis. These pathways include TLR4/NF-Formula: see textB, PI3K/AKT, TGF-Formula: see text/Smad2, ROS/caspase-1/GSDMD, Wnt/Formula: see text-catenin, AMPK/ACSS2/PPARFormula: see text, Sirt3/Drp1, and PINK1/Parkin. Although mechanistic studies have substantially advanced, the clinical application of AS-IV in MI remains in the exploratory stage. Further well-designed clinical trials are necessary in order to validate the therapeutic efficacy and safety of AS-IV, thereby facilitating its translation from experimental research to clinical practice, and offering new insights and potential strategies for MI management.
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Li et al. (Mon,) reported a other. Astragaloside IV protects against myocardial infarction by modulating multiple pathways related to anti-inflammation, anti-oxidation, antifibrosis, and mitochondrial homeostasis.
www.synapsesocial.com/papers/6994055d4e9c9e835dfd6374 — DOI: https://doi.org/10.1142/s0192415x26500205
Bin Li
Yijia Liu
Guiping Hu
The American Journal of Chinese Medicine
Beihang University
Tianjin University of Traditional Chinese Medicine
Baokang Hospital Affiliated to Tianjin University of Traditional Chinese Medicine
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