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February 19, 2026ACS Chemical Biology

Live-Cell Imaging Analysis of the Intracellular Behavior of the C-Type Lectin Receptor Mincle and Its Ligand Using Newly Developed Fluorescence-Labeled Molecular Probes Based on Trehalose Diester

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Authors

TMTakanori MatsumaruKOKana OkuboJTJuri Takayama

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Overview

Live-cell imaging reveals Mincle's behavior in response to ligands, suggesting methods for immune analysis.

Key Points

  • The aim is to investigate the intracellular behavior of the C-type lectin receptor Mincle using new molecular probes.
  • Developed TDE-Fluor-Ligand and TDE-Reactive-Probe based on trehalose diester.
  • Performed live-cell imaging analysis to observe Mincle and its ligands.
  • Analyzed the internalization of TDE-Fluor-Ligand in a Mincle-dependent manner.
  • TDE-Fluor-Ligand was internalized into cells based on Mincle expression.
  • TDE-Reactive-Probe successfully labeled Mincle, depending on its expression levels.

Cite This Study

Matsumaru et al. (2026) studied this question.

synapsesocial.com/papers/6996a768ecb39a600b3ed0b9https://doi.org/10.1021/acschembio.5c00794
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Live-cell imaging analysis of the intracellular behavior of C-type lectin receptor Mincle and its ligand using newly developed fluorescence-labeled molecular probes based on trehalose diester2025
  2. 2Protocol to identify the ligand binding site of Mincle using NMR spectroscopy2024
  3. 3Coarse-graining the recognition of a glycolipid by the C-type lectin Mincle receptor2024
  4. 4Coarse-Graining the Recognition of a Glycolipid by the C-Type Lectin Mincle Receptor2024 · 2 citations
  5. 5Lessons from mycobacteria: development and design of Mincle-targeting adjuvants2026 · 1 citations