Individual-Level Behavioral Dataset Linking Trace Eyeblink Conditioning, Contextual Fear Memory, and Home-Cage Activities in rTg4510 and Wild-Type Mice with Doxycycline Treatment

This dataset provides synchronized multimodal behavioral measurements from 36 mice across four experimental groups: wild-type and rTg4510 tauopathy mice, each tested with or without doxycycline-mediated suppression of mutant tau expression. Of these, 34 mice had complete measurements across all three behavioral paradigms and were used for analyses requiring full cross-task linkage. At six months of age, all animals underwent three standardized behavioral paradigms: home cage monitoring, ten-day trace eyeblink conditioning, and contextual fear conditioning. The individual-level data included locomotor activity, rearing duration, conditioned response metrics, eyelid closure latencies, and contextual freezing percentages. All measurements were linked using unique mouse identifiers, enabling cross-task analysis without preprocessing or imputation. The dataset was accompanied by a complete data dictionary, processing workflow diagram, and validation analyses demonstrating cross-paradigm correlations. The cross-task associations are illustrated in the main figures, with additional early phase acquisition and temporal processing correlations provided in the main figures. Provided in an open CSV format with detailed metadata, this resource supports behavioral phenotyping, machine learning applications, and the investigation of learning mechanisms in tauopathy models.