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February 19, 2026JACC Case Reports0 citationsOpen Access

“Burned-Out” Hypertrophic Cardiomyopathy

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KWKevin WunderlySASteven AjluniPOPatrick O'Hayer

Key Result

CMR combined with family history and genetic testing is crucial to diagnose burned-out hypertrophic cardiomyopathy due to its imaging overlap with other nonischemic cardiomyopathies.

Key Points

  • To explore the overlap of CMR findings in burned-out hypertrophic cardiomyopathy with other cardiomyopathies.
  • Utilized cardiac magnetic resonance (CMR) imaging to assess heart structure and function.
  • Reviewed family history and conducted genetic testing for diagnosis.
  • Compared findings with other nonischemic cardiomyopathies.
  • Identified similarities in CMR findings among burned-out HCM and various nonischemic cardiomyopathies.
  • Demonstrated the diagnostic utility of combining CMR with genetic background.
  • Emphasized the importance of thorough evaluation for accurate diagnosis.

Structured PICO

P
Population
Patient with burned-out hypertrophic cardiomyopathy (HCM)
I
Intervention
Cardiac magnetic resonance (CMR) imaging combined with family history and genetic testing
O
Outcome
Diagnosis of burned-out HCM

CMR, when combined with family history and genetic testing, is essential for differentiating burned-out hypertrophic cardiomyopathy from other overlapping nonischemic cardiomyopathies.

Abstract

The CMR findings in burned-out HCM can overlap with other nonischemic cardiomyopathies, including arrhythmogenic cardiomyopathy, cardiac sarcoidosis, chronic myocarditis, dilated nonischemic cardiomyopathy, and infiltrative cardiomyopathies such as cardiac amyloidosis. This case highlights the importance of CMR in combination with family history and genetic testing to diagnose burned-out HCM.

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Cite This Study

Wunderly et al. (2026) studied this question. CMR combined with family history and genetic testing is crucial to diagnose burned-out hypertrophic cardiomyopathy due to its imaging overlap with other nonischemic cardiomyopathies.

synapsesocial.com/papers/6996a788ecb39a600b3ed55dhttps://doi.org/10.1016/j.jaccas.2026.106940
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy2018 · 867 citations
  2. 2Prevalence and clinical significance of systolic impairment in hypertrophic cardiomyopathy2005 · 162 citations
  3. 3Desmoplakin Cardiomyopathy, a Fibrotic and Inflammatory Form of Cardiomyopathy Distinct From Typical Dilated or Arrhythmogenic Right Ventricular Cardiomyopathy2020 · 492 citations
  4. 4Hypertrophic Cardiomyopathy With Left Ventricular Systolic Dysfunction2020 · 219 citations
  5. 5Clinical Spectrum, Therapeutic Options, and Outcome of Advanced Heart Failure in Hypertrophic Cardiomyopathy2015 · 102 citations