Hemoperfusion combined with hemodialysis was associated with significantly lower shear wave elastography values and 10-year ASCVD risk compared to hemodialysis alone in uremic patients (p<0.05).
Cross-Sectional (n=118)
Does hemoperfusion combined with hemodialysis improve carotid artery elasticity measured by shear wave elastography compared to hemodialysis alone in uremic patients?
Shear wave elastography can quantitatively assess carotid artery elasticity and demonstrates that adding hemoperfusion to hemodialysis is associated with better elasticity and lower ASCVD risk in uremic patients.
valor p: p=<0.05
ABSTRACT Objective This study aimed to use shear wave elastography (SWE) to evaluate the effect of hemoperfusion (HP) on carotid artery elasticity in uremic patients treated with hemodialysis (HD). Methods Seventy‐eight uremic patients were divided into Group B (using HP + HD) and Group C (using HD) according to the dialysis method the patients already used, while 40 healthy volunteers were included as Group A. The clinical data and biochemical indices were collected. Conventional carotid parameters, including carotid intima‐media thickness (IMT), carotid artery inner diameter at the end of systole ( D s ), carotid artery inner diameter at the end of diastole ( D d ), and peak systolic flow velocity (PSV) were measured. The wall motion degree (∆ D ) and the stiffness coefficient ( β ) were calculated. SWE‐derived elastic moduli (MEmean, MEmax, and MEmin) were measured. Ten‐year cardiovascular disease risk (10‐year ASCVD risk) was calculated using the Framingham risk score (FRS). Results There was no significant difference in the D s , D d , ∆ D , and PSV among the three groups (all p > 0.05). Uremic groups exhibited elevated BUN, Scr, BUA, TG, LDL‐C, IMT, β , SWE parameters, and 10‐year ASCVD risk compared to controls ( p 0.372, p < 0.01), and demonstrated superior diagnostic accuracy (AUCs: 0.919–0.953) compared to conventional measures. Conclusion These data suggest that SWE is helpful in quantitatively assessing the change in carotid artery elasticity. It could be a useful method for monitoring the progression of atherosclerosis in uremic patients undergoing HD with or without HP and may provide guidance for clinicians to identify individuals at heightened cardiovascular risk.
Yang et al. (Sun,) conducted a cross-sectional in Uremia (n=118). Hemoperfusion + Hemodialysis vs. Hemodialysis alone was evaluated on Carotid artery elasticity evaluated by shear wave elastography (SWE) and 10-year ASCVD risk (p=<0.05). Hemoperfusion combined with hemodialysis was associated with significantly lower shear wave elastography values and 10-year ASCVD risk compared to hemodialysis alone in uremic patients (p<0.05).