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This research aims to evaluate how baseline CT imaging features and clinical indicators can predict prognosis in patients with unresectable hepatocellular carcinoma (HCC) treated with a combination of HAIC, targeted therapy, and immunotherapy.

February 19, 2026Abdominal Radiology0 citationsOpen Access

Baseline CT imaging features combined with clinical indicators predict prognosis in unresectable HCC treated with HAIC plus targeted therapy and immunotherapy

HDHaiqin Deng LLLiu Liu ZLZiyu Liu

Key Points

This research aims to evaluate how baseline CT imaging features and clinical indicators can predict prognosis in patients with unresectable hepatocellular carcinoma (HCC) treated with a combination of HAIC, targeted therapy, and immunotherapy.
Analyzed baseline CT imaging features in patients with unresectable HCC.
Assessed clinical indicators and treatment responses.
Compared survival outcomes between early treatment responders and non-responders.
Early treatment responders exhibited significantly better survival rates compared to non-responders.
Non-responders did not experience meaningful survival benefits despite receiving additional HAIC treatment cycles.

Abstract

For patients with non-peripheral washout pattern in the delayed phase on imaging, the HAIC-TI treatment represents a feasible therapeutic strategy. It is noteworthy that early treatment responders showed significantly superior survival prognosis, whereas non-responders did not attain meaningful survival advantages despite receiving additional HAIC treatment cycles.

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