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February 19, 2026Discover OncologyOpen Access

A comprehensive analysis of palmitoylation related genes in lung adenocarcinoma

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Authors

JJJianjun JiangZLZichao LiTYTianbao Yan

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Overview

Analysis identifies prognostic genes in lung adenocarcinoma, suggesting their value in predicting outcomes.

Key Points

  • The aim is to identify prognostic genes linked to palmitoylation in lung adenocarcinoma and evaluate their predictive value.
  • Used ssGSEA algorithm to calculate palmitoylation pathway scores.
  • Applied lasso regression for feature selection of palmitoylation pathway genes.
  • Developed and validated a palmitoylation-related prognostic risk score model.
  • Conducted functional enrichment analysis, immune profiling, and drug sensitivity analyses.
  • Evaluated expression levels of key genes in LUAD samples using qPCR.
  • Identified 15 hub palmitoylation pathway-related genes for the PM model.
  • Model showed moderate predictive accuracy with AUCs: 0.737, 0.693, 0.676 for survival at 1, 2, and 5 years.
  • High PM score correlates with advanced cancer stages and reduced immunotherapy responses.
  • Validated five key genes in local lung adenocarcinoma samples.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6996a7b5ecb39a600b3ed9d7https://doi.org/10.1007/s12672-026-04570-8
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