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February 19, 2026Journal of Cardiovascular Medicine0 citations

Acute coronary syndrome and coronary artery disease in wild-type transthyretin amyloid cardiomyopathy: a DIAMOND sub-study

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LML De MichieliGTGiacomo TiniAAAlessia Argirò

Key Points

  • This research aims to explore the prevalence of acute coronary syndrome and its impact on outcomes in patients with wild-type transthyretin amyloid cardiomyopathy.
  • Analyzed baseline data of patients with wild-type transthyretin amyloid cardiomyopathy
  • Identified history of acute coronary syndrome and coronary artery disease
  • Evaluated associations with adverse outcomes
  • 9% of patients had a history of acute coronary syndrome
  • History of ACS linked to increased risk of adverse outcomes
  • Obstructive coronary artery disease without ACS did not impact outcomes significantly

Abstract

Background Patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) often have cardiovascular comorbidities, including acute coronary syndrome (ACS) and coronary artery disease (CAD). Results and major findings At baseline, 9% of patients had a history of ACS and this was associated with increased risk of adverse outcomes, while this was not the case for obstructive CAD without ACS. Further prospective studies are needed to corroborate these findings.

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Cite This Study

Michieli et al. (2026) studied this question.

synapsesocial.com/papers/6996a818ecb39a600b3ee738https://doi.org/10.2459/jcm.0000000000001844
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